Moment of Inertia for Axisymmetric Neutron Stars in the Standard-Model Extension

We develop a consistent approach to calculate the moment of inertia (MOI) for axisymmetric neutron stars (NSs) in the Lorentz-violating Standard-Model Extension (SME) framework. To our knowledge, this is the first relativistic MOI calculation for axisymmetric NSs in a Lorentz-violating gravity theory other than deformed, rotating NSs in the General Relativity. Under Lorentz violation, there is a specific direction in the spacetime and NSs get stretched or compressed along that direction. When a NS is spinning stationarily along this direction, a conserved angular momentum and the concept of MOI are well defined. In the SME framework, we calculate the partial differential equation governing the rotation and solve it numerically with the finite element method to get the MOI for axisymmetric NSs caused by Lorentz violation. Besides, we study an approximate case where the correction to the MOI is regarded solely from the deformation of the NS and compare it with its counterpart in the Newtonian gravity. Our formalism and the numerical method can be extended to other theories of gravity for static axisymmetric NSs.Comment: 9 pages, 3 figure

Theoretical model and characteristics analysis of deflector-jet servo valve’s pilot stage

To analyze the deflector-jet servo valve’s internal flow characteristics, a theoretical model of the complicated flow distribution in the deflector plate is established based on the offset jet attachment theory. When the deflector plate offsets, jet attachment parameters are attained to figure out the jet’s bending and colliding process. On this basis, an analytical method of acquiring the pilot valve’s pressure gain is derived. According to an actual pilot stage’s structure, pressure gain calculations are carried out. Meanwhile, the pilot valve’s mesh model is established for numerical simulation in order to examine the accuracy of the theoretical model. Calculation and numerical simulation show that the final oil jet is not sensitive to the deflector plate’s movement, which directly reveals the pressure stabilizing effect of the V-shaped structure on the deflector plate. Moreover, the experiment on the pressure gain is accomplished and experiment results verify the accuracy of the analytical calculation

Salicylic acid receptors activate jasmonic acid signalling through a non-canonical pathway to promote effector-triggered immunity.

It is an apparent conundrum how plants evolved effector-triggered immunity (ETI), involving programmed cell death (PCD), as a major defence mechanism against biotrophic pathogens, because ETI-associated PCD could leave them vulnerable to necrotrophic pathogens that thrive on dead host cells. Interestingly, during ETI, the normally antagonistic defence hormones, salicylic acid (SA) and jasmonic acid (JA) associated with defence against biotrophs and necrotrophs respectively, both accumulate to high levels. In this study, we made the surprising finding that JA is a positive regulator of RPS2-mediated ETI. Early induction of JA-responsive genes and de novo JA synthesis following SA accumulation is activated through the SA receptors NPR3 and NPR4, instead of the JA receptor COI1. We provide evidence that NPR3 and NPR4 may mediate this effect by promoting degradation of the JA transcriptional repressor JAZs. This unique interplay between SA and JA offers a possible explanation of how plants can mount defence against a biotrophic pathogen without becoming vulnerable to necrotrophic pathogens

Stability of a class of multi-agent tracking systems with unstable subsystems

In this work, we pre-deploy a large number of smart agents to monitor an area of interest. This area could be divided into many Voronoi cells by using the knowledge of Voronoi diagram and every Voronoi site agent is responsible for monitoring and tracking the target in its cell. Then, a cooperative relay tracking strategy is proposed such that during the tracking process, when a target enters a new Voronoi cell, this event triggers the switching of both tracking agents and communication topology. This is significantly different from the traditional switching topologies. In addition, during the tracking process, the topology and tracking agents switch, which may lead the tracking system to be stable or unstable. The system switches either among consecutive stable subsystems and consecutive unstable subsystems or between stable and unstable subsystems. The objective of this paper is to design a tracking strategy guaranteeing overall successful tracking despite the existence of unstable subsystems. We also address extended discussions on the case where the dynamics of agents are subject to disturbances and the disturbance attenuation level is achieved. Finally, the proposed tracking strategy is verified by a set of simulations

An economic evaluation of a primary care-based technology-enabled intervention for stroke secondary prevention and management in rural China : a study protocol

Introduction: Secondary prevention of stroke is a leading challenge globally and only a few strategies have been tested to be effective in supporting stroke survivors. The system-integrated and technology-enabled model of care (SINEMA) intervention, a primary care-based and technology-enabled model of care, has been proven effective in strengthening the secondary prevention of stroke in rural China. The aim of this protocol is to outline the methods for the cost-effectiveness evaluation of the SINEMA intervention to better understand its potential economic benefits. Methods: The economic evaluation will be a nested study based on the SINEMA trial; a cluster-randomized controlled trial implemented in 50 villages in rural China. The effectiveness of the intervention will be estimated using quality-adjusted life years for the cost-utility analysis and reduction in systolic blood pressure for the cost-effectiveness analysis. Health resource and service use and program costs will be identified, measured, and valued at the individual level based on medication use, hospital visits, and inpatients' records. The economic evaluation will be conducted from the perspective of the healthcare system. Conclusion: The economic evaluation will be used to establish the value of the SINEMA intervention in the Chinese rural setting, which has great potential to be adapted and implemented in other resource-limited settings

Preparative Separation and Identification of the Flavonoid Phlorhizin from the Crude Extract of Lithocarpus Polystachyus Rehd

The flavonoid phlorhizin is abundant in the leaves of Sweet Tea(ST, Lithocarpus Polystachyus Rehd). Phlorhizinwas preparatively separated and purified from a crude ST extract containing 40% total flavonoids by static adsorption and dynamic desorption on ADS-7 macroporous resin and neutral alumina column chromatography. Only water and ethanol were used as solvents and eluants throughout the whole separation and purification process. Using a phlorhizin standard as the reference compound, the target compound separated from the crude ST extracts was analyzed by thin layer chromatography (TLC), high performance liquid chromatography (HPLC) and electrosprayionization mass spectrometry (EIS-MS) and identified as 99.87% pure (by HPLC-UV) phlorhizin. The results showed that 10g of the targetcompound could be obtained from 40g of the crude extracts in a single operation, indicating a 40% recovery. Therefore, this represents an efficientand environmentally-friendly technology for separating and purifying phlorhizinfrom ST leaves

Numerical analysis of the axial heat conduction with variable fluid properties in a forced laminar flow tube

This document is the Accepted Manuscript version of the following article: Lijing Zhai, et al, ‘Numerical analysis of the axial heat conduction with variable fluid properties in a forced laminar flow tube’, International Journal of Heat and Mass Transfer, Vol. 114: 238-251, November 2017. Under embargo until 22 June 2018. The final, definitive version is available online at doi: https://doi.org/10.1016/j.ijheatmasstransfer.2017.06.041.In this article, a theoretical model is developed to investigate the effects of the axial heat conduction on the laminar forced convection in a circular tube with uniform internal heat generation in the solid wall. In the current work, three different fluids, i.e. water, n-decane and air, are selected on purpose since their thermophysical properties show different behavior with temperature. The effects of the axial heat conduction with varying dynamic viscosity and/or varying thermal conductivity are investigated in a systematic manner. Results indicate that the variable-property effects could alleviate the reduction in Nusselt number (Nu) due to the axial heat conduction. For the case of Peclet number (Pe) equal to 100, wall thickness to inner diameter ratio of 1 and solid wall to fluid thermal conductivity ratio of 100, the maximum Nu deviation between constant and variable properties are up to 7.33% at the entrance part for water in the temperature range of 50℃, and 4.45% at the entrance part for n-decane in the temperature range of 120℃, as well as 2.20% at the ending part for air in the temperature range of 475℃, respectively. In addition, the average Nu deviation for water, n-decane and air are 3.24%, 1.94% and 1.74%, respectively. Besides, Nu decreases drastically with decreasing Pe when Pe≤500 and with increasing solid wall to fluid thermal conductivity ratio ( ) when ≤100. It is also found that variable properties have more obvious effects on the velocity profile at the upstream part while more obvious effects on the temperature profile at the downstream part.Peer reviewe

The rational dose for MaXingShiGan decoction is crucial for its clinical effectiveness in treating bronchial pneumonia: three randomized, double-blind, dose-parallel controlled clinical studies

Objective: Evaluate the impact of adjusting the overall dose, Gypsum Fibrosum [Mineral; Gypsum] (ShiGao, SG) dose, and Prunus armeniaca L. [Rosaceae; Semen Armeniacae Amarum] (KuXingRen, KXR) dose on the efficacy of MaXingShiGan Decoction (MXSG) in treating children with bronchial pneumonia (Wind-heat Blocking the Lung), in order to provide strategy supported by high-quality evidence for the selection of rational clinical doses of MXSG.Methods: Based on the basic dose of MXSG, we conducted three randomized, double-blind, dose parallel controlled, multicenter clinical trials, involving adjustments to the overall dose, SG dose, and KXR dose, and included 120 children with bronchial pneumonia (Wind-heat Blocking the Lung) respectively. And the patients were divided into low, medium, and high dose groups in a 1:1:1 ratio, with 40 cases in each group. The intervention period lasted for 10 days. The primary outcome was the clinical cured rate, while the secondary outcomes included the effectiveness in alleviating major symptoms of bronchial pneumonia (including fever, cough, dyspnea, and phlegm congestion). And the occurrence of adverse events was recorded.Results: We first recorded and analyzed the baseline characteristics of the three studies, including age, gender, height, and so on. The results indicated that there were no significant differences among the dose groups within each study. For the study adjusting the overall dose of MXSG, the results showed that both the medium-dose group and high-dose group had significantly higher clinical cured rates compared to the low-dose group (Chi-square value 9.01, p = 0.0111). However, there was no significant benefit between the high-dose group and the medium-dose group (81.58% vs. 81.08%). Regarding phlegm congestion, excluding fever, cough, and dyspnea, both the medium-dose group and high-dose group had significantly higher clinical cured rates than the low-dose group (Chi-square value 6.31, p = 0.0426), and there was no significant benefit between the high-dose group and the medium-dose group (69.23% vs. 75.00%). A total of 5 adverse events were observed, of which only 1 case in the medium-dose group was possibly related to the experimental medication. For the study adjusted the SG dose in MXSG, the results showed that the high-dose group had the highest clinical cured rate, but the inter-group difference was not statistically significant (Chi-square value 3.36, p = 0.1864). The area under the curve (AUC) for cough in the medium-dose group was significantly lower than in the low-dose group and high-dose group (F-test value 3.14, p = 0.0471). Although no significant differences were observed in fever and dyspnea among the groups, the AUC in the high-dose group was lower than in the medium-dose and low-dose groups. In comparing the complete defervescence time, both the high-dose group (p < 0.0001) and the medium-dose group (p = 0.0015) achieved faster than the low-dose group. The high-dose group slightly outperformed the medium-dose group (0.50 (0.50, 0.80) vs. 0.80 (0.40, 1.40)), although the difference was not significant. In the medium-dose group, 1 adverse event was observed, but it was not related to the experimental medication. For the study adjusted the KXR dose in MXSG, the results showed that both the medium-dose group and high-dose group had significantly higher cured rates compared to the low-dose group (Chi-square value 47.05, p < 0.0001). However, there was no significant benefit comparing the high-dose group to the medium-dose group (90.00% vs. 92.50%). Regarding clinical symptoms, the results indicated that for cough (F-test value 3.16, p = 0.0460) and phlegm congestion (F-test value 3.84, p = 0.0243), the AUC for both the medium-dose group and high-dose group were significantly lower than in the low-dose group. Although there was benefit in the high-dose group compared to the medium-dose group, it was not statistically significant. No adverse events were observed during the study period.Conclusion: The synthesis of the three conducted clinical studies collectively indicates that for children with bronchial pneumonia (Wind-heat Blocking the Lung), the basic clinical dose of MXSG may represents an optimal intervention dose based on the accumulated clinical experience of doctors. If the dose is insufficient, the clinical effects might be compromised, but using a higher dose does not significantly enhance benefits. Concerning different symptoms, increasing the overall formula’s dose has a favorable impact on improving phlegm congestion, increasing the SG is effective in improving symptoms such as fever, cough, and dyspnea, while higher dose of KXR is effective in alleviating cough and phlegm congestion. These findings suggest that for MXSG, achieving the optimal intervention dose is crucial to achieve better clinical efficacy. For the SG and KXR, if certain symptoms are more severe, increasing the dose can be considered within safe limits, can lead to significant clinical benefits in symptom improvement. This also explains why the dose of MXSG might vary among clinical doctors, while maintaining a balance between safety and effectiveness. Of course, our study is still exploratory clinical trials, and further studies are needed to confirm our findings.Clinical Trial Registration:https://www.chictr.org.cn/index.html; Identifier: ChiCTR-TRC-13003093, ChiCTR-TRC-13003099

More than 50 years of successful continuous temperature section measurements by the global expendable bathythermograph network, its integrability, societal benefits, and future

The first eXpendable BathyThermographs (XBTs) were deployed in the 1960s in the North Atlantic Ocean. In 1967 XBTs were deployed in operational mode to provide a continuous record of temperature profile data along repeated transects, now known as the Global XBT Network. The current network is designed to monitor ocean circulation and boundary current variability, basin-wide and trans-basin ocean heat transport, and global and regional heat content. The ability of the XBT Network to systematically map the upper ocean thermal field in multiple basins with repeated trans-basin sections at eddy-resolving scales remains unmatched today and cannot be reproduced at present by any other observing platform. Some repeated XBT transects have now been continuously occupied for more than 30 years, providing an unprecedented long-term climate record of temperature, and geostrophic velocity profiles that are used to understand variability in ocean heat content (OHC), sea level change, and meridional ocean heat transport. Here, we present key scientific advances in understanding the changing ocean and climate system supported by XBT observations. Improvement in XBT data quality and its impact on computations, particularly of OHC, are presented. Technology development for probes, launchers, and transmission techniques are also discussed. Finally, we offer new perspectives for the future of the Global XBT Network

XBT Science: Assessment of Instrumental Biases and Errors

Expendable bathythermograph (XBT) data were the major component of the ocean temperature profile observations from the late 1960s through the early 2000s, and XBTs still continue to provide critical data to monitor surface and subsurface currents, meridional heat transport, and ocean heat content. Systematic errors have been identified in the XBT data, some of which originate from computing the depth in the profile using a theoretically and experimentally derived fall-rate equation (FRE). After in-depth studies of these biases and discussions held in several workshops dedicated to discussing XBT biases, the XBT science community met at the Fourth XBT Science Workshop and concluded that XBT biases consist of 1) errors in depth values due to the inadequacy of the probe motion description done by standard FRE and 2) independent pure temperature biases. The depth error and temperature bias are temperature dependent and may depend on the data acquisition and recording system. In addition, the depth bias also includes an offset term. Some biases affecting the XBT-derived temperature profiles vary with manufacturer/probe type and have been shown to be time dependent. Best practices for historical XBT data corrections, recommendations for future collection of metadata to accompany XBT data, impact of XBT biases on scientific applications, and challenges encountered are presented in this manuscript. Analysis of XBT data shows that, despite the existence of these biases, historical XBT data without bias corrections are still suitable for many scientific applications, and that bias-corrected data can be used for climate research